NET Framework Assistant and its only focus are exactly ClickOnce programs. Nonetheless, since most of the big names in this category, like Firefox for example, can be extended through the use of add-ons, it is highly likely that there are some to make handling these files more easily. Deploying these special applications is not possible from just about any web browser you may be using and most of these apps will have to be downloaded and then installed from the PC.
Installing Windows software is usually a simple job, but there are some technologies that can make this activity even more facile and ClickOnce is one of them.
